Table 5.
The relationship between parameters and survival in patients with mGPS = 1 (n = 290).
| Parameter | Patients | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| N | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | |||||
| <60/60–69/70–79/≥80 | 33/71/89/28 | 1.24 (1.09–1.40) | 0.001 | — | — |
| Sex | |||||
| Male | 174 | 1 | 0.171 | — | — |
| Female | 130 | 0.84 (0.66–1.08) | — | — | — |
| Centre | |||||
| Aberdeen | 145 | 1 | 0.425 | — | — |
| Fife | 23 | 0.89 (0.55–1.43) | — | — | — |
| Stobhill | 55 | 0.99 (0.72–1.36) | — | — | — |
| Inverclyde | 67 | 1.23 (0.92–1.66) | — | — | — |
| Deprivation (quintile) (most deprived = 1, least deprived = 5) | |||||
| 1/2/3/4/5 | 75/47/75/77/30 | 0.99 (0.90–1.08) | 0.777 | — | — |
| Smoking history (NS = never smoker, otherwise pack years) | |||||
| NS/<20/20–60/>60 | 11/33/177/69 | 1.02 (0.86–1.22) | 0.792 | — | — |
| Performance status | |||||
| 0/1/2/3/4 | 26/130/105/40/3 | 1.83 (1.57–2.14) | <0.001 | 1.81 (1.55–2.13) | <0.001 |
| Weight loss (% body weight) | |||||
| 0/<5/5–10/>10 | 181/48/53/22 | 1.15 (1.06–1.25) | 0.001 | — | — |
| FEV1 (%) | |||||
| >80/80–60/59–40/<40 | 138/31/45/7 | 0.94 (0.83–1.06) | 0.313 | — | — |
| Local symptoms | |||||
| No/yes | 18/222 | 1.60 (0.91–2.80) | 0.105 | — | — |
| Stage | |||||
| NSCLC | |||||
| I/II/IIIa/IIIb/IV | 15/19/20/56/84 | 1.31 (1.19–1.45) | <0.001 | 1.08 (1.03–1.13) | 0.002 |
| SCLC | |||||
| Limited/extensive | 10/32 | 0.51 (0.23–1.11) | 0.091 | — | — |
| Treatment | |||||
| Radical | |||||
| BSC/surgery/RT | 43/17/15 | 0.55 (0.41–0.72) | <0.001 | 0.70 (0.52–0.94) | 0.017 |
| Palliative | |||||
| Chemo/RT/BSC | 107/58/55 | 1.07 (0.90–1.26) | 0.436 | — | — |