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. 2015 May 13;7(1):39. doi: 10.1186/s13073-015-0162-2

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© Mirza et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Correlations of expression for cis-neighboring pairs of IBD loci-associated differentially expressed lncRNAs and protein-coding genes. (A-F) Overall positive correlations between overlapping protein-coding and lncRNA gene-pairs: LSP1 and ENST00000509204.1 (A); HLA-DQB1 and ENST00000443574.1 (B); MST1 and ENST00000563780.1 (C); TSPAN33 and ENST00000498745.1 (D); SLC22A5 and ENST00000417795.1 (E); DGRD and ENST00000442524.1 (F). An extremely positive (r² ≥ 0.99, P-value <2.2e-16) correlation was observed for MST1 and its intersecting lncRNA ENST00000563780.1, which is associated with IBD risk variants rs9822268 and rs3197999. Protein-coding expression is plotted on the x-axis, and lncRNA expression is shown on the y-axis. Each point represents a biopsy sample from different clinical subgroups.