Table 4.
Top 10 differentially expressed lncRNA and protein-coding genes in inflamed Crohn’s disease
| Gene name | Transcript | FC |
|---|---|---|
| Up-regulated lncRNAs | ||
| RP11-731 F5.2 | ENST00000460164.1 | 14.14 |
| MMP12 | ENST00000532855.1 | 6.64 |
| MMP12 | ENST00000326227.5 | 6.52 |
| RP11-465 L10.10 | ENST00000419897.1 | 5.69 |
| RP11-44 K6.2 | ENST00000520185.1 | 3.83 |
| FAM66D | ENST00000526690.1 | 3.36 |
| LINC01272 | ENST00000445003.1 | 3.35 |
| RP11-44 K6.4 | ENST00000522970.1 | 3.24 |
| SAA2-SAA4 | ENST00000524555.1 | 3.16 |
| KIF9-AS1 | ENST00000429315.2 | 3.14 |
| Down-regulated lncRNAs | ||
| DPP10-AS1 | ENST00000432658.1 | -8.57 |
| PDZK1P2 | ENST00000401008.2 | -4.11 |
| DIO3OS | ENST00000553575.1 | -3.01 |
| DIO3OS | ENST00000554694.1 | -3.01 |
| DIO3OS | ENST00000557532.1 | -2.99 |
| DIO3OS | ENST00000557109.1 | -2.98 |
| ANRIL (CDKN2B-AS1) | ENST00000422420.1 | -2.97 |
| ANRIL (CDKN2B-AS1) | ENST00000428597.1 | -2.97 |
| DIO3OS | ENST00000554441.1 | -2.96 |
| DIO3OS | ENST00000554735.1 | -2.95 |
| Up-regulated protein-coding genes | ||
| REG3A | NM_138938 | 52.71 |
| DUOXA2 | NM_207581 | 47.26 |
| DEFA5 | NM_021010 | 37.73 |
| DEFA6 | NM_001926 | 28.33 |
| CHI3L1 | NM_001276 | 26.29 |
| CXCL1 | NM_001511 | 14.8 |
| DMBT1 | NM_007329 | 13.45 |
| SAA1 | NM_000331 | 12.67 |
| CXCL9 | NM_002416 | 12.07 |
| IGHG3 | ENST00000390551 | 11.52 |
| Down-regulated protein-coding genes | ||
| PCK1 | NM_002591 | -5.55 |
| SLC26A2 | NM_000112 | -3.82 |
| C10orf116 | NM_006829 | -3.8 |
| GUCA2B | NM_007102 | -3.61 |
| LCN15 | NM_203347 | -3.43 |
| AQP7P1 | NR_002817 | -3.32 |
| TRPM6 | NM_017662 | -3.19 |
| TNNC2 | NM_003279 | -3.1 |
| UGT2A3 | NM_024743 | -2.97 |
| ADH1C | NM_000669 | -2.96 |
Top 10 up- and down-regulated lncRNAs and protein-coding genes in iCD versus control comparison. The log2 fold change is denoted as FC.