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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Curr Opin HIV AIDS. 2015 May;10(3):135–143. doi: 10.1097/COH.0000000000000153

FIGURE 1.

FIGURE 1

The V2 site overlaps with the N332 supersite. The HIV-1 envelope (Env) trimer is shown in light (gp120) and dark (gp41) grey surface view. An expanded graphic of the V2 and N332 sites is shown in the zoomed out box. Epitopes in V2 (red), V3 (orange), or V4 (yellow) are defined as residues within 5 Å of broadly neutralizing antibodies (bNAbs) PG9, PGT122/PGT128, or PGT135, respectively. Regions of overlap between epitopes are shown with mottled colours red/orange for V2-V3, and orange/yellow for V3–V4. Key glycans are shown as spheres, labelled, and coloured according to their epitopes. Glycans predicted to be a part of the 2G12 epitope are coloured dark grey, and bordered with a dotted line. Glycans N156, N332, and N392 that are bound by bNAbs targeting different epitopes are asterisked. Proximal hypervariable regions V1 and α2 are shown in light grey. Figure based on protein databank accession code 4TVP.

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