Figure 6.

Delayed Regenerative Profiles following Depletion of Lgr5⁺ Cells

(A and B) Immunofluorescence of BrdU in the anterior lobes of prostate sections from Lgr5^DTR.EGFP mice administered either PBS (A) or DT (B). The insets are enlarged images of the boxed areas.

(C) Quantification of BrdU⁺ cells as a percentage of total epithelial cells in the anterior lobes of prostates: DT, 8.6%, cn = 11,242, n = 3 mice; PBS, 1.5%, cn = 9145, n = 3 mice; p = 0.005.

(D) Transcriptional analysis of prostate tissue following Lgr5⁺ cell depletion; n = 4 animals per group.

All values are represented as mean and SEM. ^∗p < 0.05, ^∗∗p < 0.01.