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Molecular components of the circadian oscillator in diverse eukaryotic organisms. Components of the molecular oscillator are categorized by their involvement in the positive or negative arm of the oscillator. Clock genes in animals show strong sequence conservation, and evolutionary relatedness between the positive elements WC-1 in Neurospora and BMAL1 in mammals has been described (Lee et al., 2000; Tauber et al., 2004).
