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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Bone. 2014 Nov 29;72:92–100. doi: 10.1016/j.bone.2014.11.018

Figure 4. EP1−/− mice show increased bone formation and normal bone resorption.

Figure 4

Calcein labeling was performed on 10 week-old EP1−/− and WT mice. Sections of [A] Tibia and [B] Calvaria were examined by fluorescence microscopy and mineral apposition rates (MAR) and bone formation rates (BFR) were quantified. [C] Femurs from 2 month-old EP1−/− and WT mice underwent TRAP staining to identify TRAP+ osteoclasts; Osteoclast number/bone surface (Oc.N./BS) and osteoclast surface/bone surface (Oc.S./BS) were quantified. Statistical comparisons were performed using Student’s t-test. 5 mice, 3 levels per mouse, were tested in each group, N = 5. (*) = p < 0.05 v.s. WT. Not significant is denoted as “NS”.