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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Neuroimage. 2014 Jul 16;101:625–632. doi: 10.1016/j.neuroimage.2014.07.017

Fig. 3.

Fig. 3

Spinal Cord Pathology. Lateral view of a 3D image stack of the dorsal corticospinal tract from cervical to thoracic segments from a healthy control (CON) (A) and an EAE mouse (B/C). Note the absence of axonal ovoids in the healthy control compared to the EAE mouse (arrows). (C/D) Dorsal corticospinal tract Thy1-YFP+ axons ended in axonal bulbs in the EAE mouse (arrows). (E) 61% of axons from the EAE mice had least one ovoid on each axon. (F) Ovoid positive axons contained an average of 22 ovoids. (G) 8% of axons from the EAE mice had least one axonal end bulb. Virtually no ovoids nor end bulbs were observed in healthy control mice. n = 5. *p = 0.0003, **p = 0.002, ***p = 0.0033. T-test analysis. Error bars indicate SEM.