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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Dec 4;25(4):963–968. doi: 10.1016/j.bmcl.2014.11.067

Table 1.

SAR of Phenyl acetamide derivatives

graphic file with name nihms688607u2.jpg
Cmpd R1 IC50, um
20 graphic file with name nihms688607t1.jpg 12
35 graphic file with name nihms688607t2.jpg >100
36 graphic file with name nihms688607t3.jpg 50
37 graphic file with name nihms688607t4.jpg 30
38 graphic file with name nihms688607t5.jpg 25
39 graphic file with name nihms688607t6.jpg 10
40 graphic file with name nihms688607t7.jpg >100
41 graphic file with name nihms688607t8.jpg 11
42 graphic file with name nihms688607t9.jpg >100
43, 4-py
44, 3-py
45, 2-py 		graphic file with name nihms688607t10.jpg >100
85
55
graphic file with name nihms688607t11.jpg
46 I C50 = 3 uM
graphic file with name nihms688607t12.jpg
47 IC50 = 0.6 uM