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. 2015 May 14;8:1043–1051. doi: 10.2147/OTT.S70691

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© 2015 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Tyrphostin AG1296 suppresses viability of PLX4032-resistant melanoma cells.

Notes: (A, B) A375 and SK-MEL-5 cells were induced to become PLX4032-resistant cells (A375R and SK-MEL-5R) by incubation with gradually reducing doses of PLX4032. PLX4032 sensitivity was then examined by cell viability assay. (C, D) Both PLX4032-sensitive and PLX4032-resistant cells were treated with tyrphostin AG1296 (0.625–20 μM) for 72 hours, followed by measurement of cell viability. (E) A375 cells were treated with tyrphostin AG1296 together with PLX4032 for 72 hours, followed by measurement of cell viability.

Abbreviations: T, tyrphostin AG1296; P, PLX4032.