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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Curr Pharm Des. 2012;18(8):1131–1147. doi: 10.2174/138161212799315786

Fig. (1). Schematic diagram of APP mutations and its amyloidogenic effect.

Fig. (1)

Amyloid precursor protein (APP) is a type I transmembrane protein, and within its sequence, amyloid-β(Aβ) resides. APP is proteolytically cleaved by α-, β-, and γ-secretase activities, and α-secretase cleavage precludes toxic Aβ to be produced. FAD-linked genetic mutations on APP exhibit different effects on APP processing and amyloidogenic properties of Aβ peptides. Please refer main text for detailed explanation.