Amyloid precursor protein (APP) is a type I transmembrane protein, and within its sequence, amyloid-β(Aβ) resides. APP is proteolytically cleaved by α-, β-, and γ-secretase activities, and α-secretase cleavage precludes toxic Aβ to be produced. FAD-linked genetic mutations on APP exhibit different effects on APP processing and amyloidogenic properties of Aβ peptides. Please refer main text for detailed explanation.