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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Neurosci Lett. 2014 Jun 2;575:96–100. doi: 10.1016/j.neulet.2014.05.047

Fig. 1.

Fig. 1

Immunization with the AT8-antibody reduces somatodendritic tau immunoreactivity. Total tau levels were quantified in 15–18-month-old 3xTg-AD mice following a single intrahippocampal injection with AT8 or a control IgG. Mice were sacrificed at post injection day 7, 14, 21, or 28. (A) Immunohistochemical analysis reveled sharp decreases in total tau (HT7) levels after immunization with AT8 at days 7 and 14, but not days 21 and 28. (B) Statistical analysis of the change in total tau between AT8 treated and control IgG treated hippocampal sides (t-test, ***P < 0.0001, **P < 0.008, N = 3–7). Scale bar equals 500 µm.