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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Neurosci Lett. 2014 Jun 2;575:96–100. doi: 10.1016/j.neulet.2014.05.047

Fig. 3.

Fig. 3

Immunization with the 4G8-antibody reduces intra- and extracellular Aβ. In addition to treatment with AT8, a small cohort of 15–18-month-old 3xTg-AD mice was treated with either the anti-Aβ antibody 4G8 or a control IgG. (A) Staining for total Aβ load (6E10) revealed that 4G8 injection drastically reduced intra- and extracellular Aβ at days 7 and 14. (B) Statistical analysis of Aβ immunization in 4G8 vs. control IgG hippocampal sections (t-test, ***P < 0.0003, **P < 0.0057, N = 3–7). Scale bar equals 500 µm.