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. 2015 May 19;10(5):e0127288. doi: 10.1371/journal.pone.0127288

Fig 10. Proposed mechanisms for the mononuclear iron dependent DMSP lyase, DddW.

Fig 10

DddW binds to Fe(II) cofactor to which the substrate can coordinate in either monodentate or bidentate modes. (A) His81 can act as a nucleophile to remove a hydrogen atom from the α-carbon of DMSP to form acrylate. (B) A hypothetical water molecule can be activated by His81, which then acts as a nucleophile in initiating catalysis. (C) Tyr89 located near the active site can initiate the elimination reaction cleaving DMSP.