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. 2015 May 14;8:49. doi: 10.1186/s13045-015-0142-4

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© Kim et al. ; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Tissue expression of CXCL13 and CXCR5, and its correlation with GPS and stage. (A) Representative ENKTL case with negative CXCL13 staining (×400). (B) CXCR5 antibody stains the cytoplasm of ENKTL tumor cells and B-cells in a normal germinal center. (C) There were significantly more patients with high CXCL13 in the GPS 2 group than in the GPS 0 or 1 groups (P < 0.05). (D) More patients have high CXCL13 with stage III/IV disease than do patients with stage I/II (P < 0.05).