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. Author manuscript; available in PMC: 2015 May 19.
Published in final edited form as: Q Rev Biophys. 2013 May;46(2):181–209. doi: 10.1017/S0033583513000024

Table 3.

Percentages of ionizable residues in receptor proteins that exhibit substantial pK change (|ΔpK | > 1) upon ligand binding in the biologically relevant pH range from 4 to 8. Adopted from Aguilar et al.1

Complex type Minimum Average Maximum
Protein-protein (20) 1.5% 8.7% 16.7%
Protein-small molecule (20) 2.1% 5.7% 12.5%
Protein-nucleic acid (20) 5.6% 12.3% 24.4%