Table 1. General and biochemical parameters of rats in different groups.
| Parameters | Control | NAFL | NASH | NAFL + T2DM |
|---|---|---|---|---|
| General parameters | ||||
| Body weight(g) | 545.8 ± 12.86 | 681.0 ± 2 8.47* | 313.7± 9.22*,§ | 657.6 ± 23.81* |
| Liver weight(g) | 14.01 ± 0.35 | 20.26 ± 1.14* | 16.52 ± 0.65§ | 20.67 ± 1.2* |
| Liver index(%) | 2.57 ± 0.06 | 2.98 ± 0.12* | 5.28 ± 0.19*,§ | 3.13 ± 0.09* |
| Biochemical parameters | ||||
| ALT(U/L) | 42.3 ± 2.53 | 147.9 ± 32.75 | 422.9 ± 63.58*,§ | 102.6 ± 16.73 |
| AST(U/L) | 107.7 ± 3.5 | 190.3 ± 22.48 | 587.9 ± 66.0*,§ | 171.2 ± 19.2 |
| TBil(umol/L) | 2.18 ± 0.17 | 2.25 ± 0.14 | 6.24 ± 0.44*,§ | 1.89 ± 0.11 |
| TC(mmol/L) | 1.74 ± 0.16 | 1.92 ± 0.07 | 2.09 ± 0.27 | 1.46 ± 0.1 |
| TG(mmol/L) | 0.80 ± 0.06 | 1.35 ± 0.20* | 1.70 ± 0.24* | 1.66 ± 0.17* |
| HDL(mmol/L) | 0.37 ± 0.02 | 0.4 ± 0.01 | 0.35 ± 0.05 | 0.37 ± 0.03 |
| LDL(mmol/L) | 0.13 ± 0.01 | 0.38 ± 0.2 | 0.78 ± 0.17*,§ | 0.08 ± 0.01 |
| FBG(mmol/L) | 4.90 ± 0.12 | 6.68 ± 0.27* | 4.37 ± 0.17 | 13.65 ± 0.99*,§ |
| FINS(mIU/L) | 8.50 ± 0.8 | 23.73 ± 1.99* | 7.06 ± 0.62§ | 17.66 ± 1.62*,§ |
| HOMA-IR | 1.85 ± 0.18 | 7.15 ± 0.8* | 1.35 ± 0.11§ | 11.29 ± 1.43*,§ |
Data are expressed as the mean ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBil, total bilirubin; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FBG, fasting blood glucose; FINS, fasting insulin; HOMA-IR, homeostasis model assessment of insulin resistance.
*P < 0.05 compared with control group
§ P < 0.05 compared with NAFL group.