Table 3.
Relative risks (RR) of breast cancer and 95% confidence intervals (CI) according to quartile of premenopausal FlOP levels (FI/mL)
| RR | RR 95% CI | RR 95% CI | RR 95% CI | Ptrend | ||
|---|---|---|---|---|---|---|
| FlOP_360 | ||||||
| Quartile Cutpoints | <176 | ≥176 to <209 | ≥209 to <252 | ≥252 | ||
| Case/Control No. | 216/187 | 172/192 | 200/193 | 176/192 | ||
| Unadjusted RR (95% CI) | 1.0 | (reference) | 0.77 (0.57, 1.02) | 0.90 (0.67, 1.20) | 0.77 (0.57, 1.04) | 0.21 |
| Multivariate RRa (95% CI) | 1.0 | (reference) | 0.71 (0.52, 0.96) | 0.85 (0.63, 1.16) | 0.68 (0.50, 0.95) | 0.07 |
| FlOP_320 | ||||||
| Quartile Cutpoints | <271 | ≥271 to <339 | ≥339 to <453 | ≥453 | ||
| Case/Control No. | 193/179 | 200/184 | 172/180 | 161/183 | ||
| Unadjusted RR (95% CI) | 1.0 | (reference) | 0.99 (0.74, 1.33) | 0.86 (0.62, 1.19) | 0.80 (0.58, 1.09) | 0.11 |
| Multivariate RRa (95% CI) | 1.0 | (reference) | 0.97 (0.71, 1.32) | 0.83 (0.59, 1.16) | 0.76 (0.55, 1.06) | 0.08 |
| FlOP_400 | ||||||
| Quartile Cutpoints | <53 | ≥53 to <64 | ≥64 to <79 | ≥79 | ||
| Case/Control No. | 177/190 | 200/194 | 208/192 | 186/195 | ||
| Unadjusted RR (95% CI) | 1.0 | (reference) | 1.12 (0.83, 1.51) | 1.17 (0.87, 1.58) | 1.04 (0.77, 1.42) | 0.96 |
| Multivariate RRa (95% CI) | 1.0 | (reference) | 1.14 (0.83, 1.56) | 1.14 (0.83, 1.57) | 1.03 (0.74, 1.44) | 0.92 |
a
Adjusted for BMI at blood draw (<25, 25-<25.9, ≥30 kg/m2), age at menarche (≤11, 12, 13, ≥14 years old), alcohol intake (non-drinker, ≤5, 5.01–10, 10.01–15, >15 grams/day), parity/age at first birth (nulliparous, 1 child/<25 years old, 1 child/ ≥25 years old, ≥2 children/<25 years old, ≥2 children/ ≥25 years old), family history of breast cancer (yes/no), history of BBD (yes/no)