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. Author manuscript; available in PMC: 2016 Jul 5.
Published in final edited form as: Int J Pharm. 2015 Apr 15;488(0):33–43. doi: 10.1016/j.ijpharm.2015.04.031

Table 4.

Pharmacokinetic parameters of plain drugs, SOD and fasudil, and formulations containing both drugs.

Drug Treatment / Route Cmax (μg/ml) t½ (hrs) AUC0→inf (μg/ml*hr)
Fasudil Plain IV 3.83±0.29 0.57±0.03 7.17±3.42
Plain IT 1.64±0.31 1.49±0.09 15.62±4.21
Plain combination IT 1.59±0.45 1.52±0.05 16.83±3.99
Liposomes IT 0.79±0.25 4.21±0.17 14.01±3.27
CAR-Liposomes IT 0.74±0.37 4.53±0.26 13.85±5.82
SOD Plain IV 5.78±0.24 0.89±0.04 9.31±2.75
Plain IT 1.45±0.28 2.24±0.03 27.78±6.91
Plain combination IT 1.41±0.57 2.35±0.08 27.69±8.19
Liposomes IT 0.83±0.27 6.32±0.29 18.41±9.81
CAR-Liposomes IT 0.77±0.19 6.75±0.18 19.75±5.28

Data represent mean ± standard deviation (n=3).