Table 2.

Metabolic and hormonal parameters of vehicle-treated and C21-untreated female Ovi C57BL/6 mice fed on ND and HFD (12-week protocol)

Parameters/Mice groups	ND	HFD	ND-C21	HFD-C21
Total Kcal intake, in 12 weeks	722±23.6	933±25.8*	716±27.2	866±33.3
Change in body weight in 12 weeks, g	14.0±0.29	27.3±1.21*	14.7±0.32	22.49±1.10#
pWAT weight / body weight, mg/g	49.1±4.9	141.9±21.4*	59.7±3.5	99.1±17.7#
Plasma Insulin (fasting), ng/mL	0.13±0.02	0.69±0.05*	0.16±0.02	0.37±0.06#
Plasma Insulin (non-fasting), ng/mL	0.24±0.03	2.86±0.53*	0.21±0.03	1.28±0.06#
Urinary E2, pg/24 h urine	38.82±2.6	10.5±1.3*,ev	40.6±2.0	14.6 ±0.7 #,ev

ND - Normal Diet, HFD - High-Fat Diet, ND-C21 - Normal Diet on C21, HFD-C21 High-Fat Diet on C21

^*Significantly different from ND group

^#significantly different from HFD. Data analyzed using one-way ANOVA with Newman-keuls post hoc test and Student t test (p<0.05); n = 4-9.

^evExtrapolated value.