Table 3.
Risk of Venous Thromboembolism with Statin and Non-Statin Lipid Lowering Therapy Compared Individually to No Lipid Lowering Therapy
| Model | Statin Lipid Lowering Therapy |
Non-Statin Lipid Lowering Therapy |
||||
|---|---|---|---|---|---|---|
| Odds Ratio |
95% Confidence Interval |
P- value |
Odds Ratio |
95% Confidence Interval |
P- value |
|
| Unadjusted | 0.78 | (0.57, 1.07) | 0.12 | 0.72 | (0.45, 1.14) | 0.16 |
| Adjusted for‡: BMI |
0.76 | (0.55, 1.04) | 0.09 | 0.71 | (0.44, 1.13) | 0.15 |
| Trauma / fracture | 0.78 | (0.57, 1.08) | 0.14 | 0.75 | (0.47, 1.21) | 0.24 |
| Hospitalized+/− surgery† | 0.60 | (0.41, 0.89) | 0.01 | 0.65 | (0.37, 1.13) | 0.13 |
| Active cancer | 0.86 | (0.61, 1.20) | 0.36 | 0.71 | (0.43, 1.18) | 0.19 |
| Neurological disease, with Leg paresis |
0.80 | (0.58, 1.10) | 0.17 | 0.68 | (0.42, 1.10) | 0.12 |
| Pacemaker/ catheter | 0.65 | (0.46, 0.92) | 0.01 | 0.71 | (0.43, 1.17) | 0.18 |
| Varicose veins | 0.80 | (0.58, 1.10) | 0.16 | 0.74 | (0.46, 1.17) | 0.20 |
| Nursing home*§ | 0.80 | (0.59, 1.10) | 0.17 | 0.72 | (0.45, 1.15) | 0.17 |
| Prior Superficial Thrombosis |
0.80 | (0.58, 1.11) | 0.18 | 0.72 | (0.45, 1.16) | 0.18 |
| Oral Contraceptives | 0.78 | (0.57, 1.07) | 0.12 | 0.72 | (0.45, 1.14) | 0.16 |
| Pregnancy/Postpartum | 0.78 | (0.57, 1.07) | 0.12 | 0.72 | (0.45, 1.14) | 0.16 |
| Estrogen/Progesterone/Oral Contraceptives |
0.79 | (0.58, 1.09) | 0.15 | 0.71 | (0.45, 1.14) | 0.16 |
| Diabetes | 0.75 | (0.54, 1.02) | 0.07 | 0.72 | (0.45, 1.15) | 0.17 |
| CHF | 0.74 | (0.54, 1.03) | 0.07 | 0.75 | (0.47, 1.21) | 0.24 |
| Angina/MI | 0.63 | (0.45, 0.87) | 0.005 | 0.61 | (0.38, 0.99) | 0.04 |
| Stroke | 0.73 | (0.53, 1.00) | 0.05 | 0.69 | (0.43, 1.10) | 0.11 |
| Peripheral Vascular Disease |
0.75 | (0.55, 1.03) | 0.08 | 0.69 | (0.43, 1.10) | 0.12 |
| Ever Smoker | 0.78 | (0.57, 1.07) | 0.13 | 0.72 | (0.45, 1.14) | 0.16 |
| Warfarin | 0.77 | (0.57, 1.06) | 0.11 | 0.72 | (0.45, 1.14) | 0.16 |
| Heparin | 0.79 | (0.57, 1.09) | 0.15 | 0.73 | (0.46, 1.18) | 0.20 |
| All of the above factors | 0.66 | (0.41, 1.08) | 0.10 | 0.71 | (0.34, 1.47) | 0.36 |
‡
Modeling was done using conditional logistic, however all models were adjusted for age at event or index since the matching was within ± 1 year; there were no missing values.
†
In hospital or within 92 days of previous hospitalization compared to no hospitalization in the past 92 days. Within the 3 months prior, the hospitalization occurred in the contest of a surgery or an acute medical illness (2 level variable).
*
All nursing home patients including those in hospital or in hospital in the previous 92 days.
§
Two cases are missing nursing home confinement data.