Table 1.
Probes significantly associated (pcor<0.05) with lifetime PTSD in the white non-Hispanic male discovery cohort of n=143 cases and 28 controls, and meta-analysis of two diverse replication cohorts: a VA cohort of 51 cases and 22 controls and the DNHS cohort of 64 cases and 65 controls.
VA Discovery Sample | VA Rep. Sample | DNHS Rep. Sample | META analysis of Rep. | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IlluminaID | Gene** | t | p | pcor | t | p | pcor | t | p | pcor | ED*** | pmeta | pcor |
ILMN_1658420 | DSCAM | −4.88 | 2.77E-06* | 0.010* | −2.14 | 0.036* | 0.32 | 0.17 | 0.87 | 0.89 | -+ | 0.27 | 0.51 |
ILMN_1729495 | TRIM41 | −4.87 | 2.92E-06* | 0.010* | −0.069 | 0.95 | 0.97 | −0.53 | 0.59 | 0.86 | -- | 0.64 | 0.77 |
ILMN_1756873 | USP48 | −4.87 | 2.94E-06* | 0.010* | −0.84 | 0.40 | 0.67 | −1.93 | 0.055 | 0.41 | -- | 0.041* | 0.24 |
ILMN_1755990 | ATP6AP1L | −4.77 | 4.61E-06* | 0.012* | −1.45 | 0.15 | 0.49 | −3.67 | 0.00036* | 0.015* | -- | 0.00019* | 0.0078* |
ILMN_1652306 | MEGF10 | −4.67 | 6.92E-06* | 0.012* | −0.53 | 0.60 | 0.72 | −0.49 | 0.62 | 0.86 | -- | 0.48 | 0.61 |
ILMN_1735353 | IRX1 | −4.67 | 6.92E-06* | 0.012* | −1.50 | 0.14 | 0.49 | −0.39 | 0.70 | 0.86 | -- | 0.24 | 0.49 |
ILMN_2309156 | PMEPA1 | −4.64 | 7.98E-06* | 0.012* | −1.31 | 0.20 | 0.49 | −2.28 | 0.024* | 0.33 | -- | 0.010* | 0.10 |
ILMN_1708337 | NOXO1 | −4.45 | 1.75E-05* | 0.023* | −0.54 | 0.59 | 0.72 | −1.00 | 0.32 | 0.86 | -- | 0.26 | 0.51 |
ILMN_1729645 | BBC3 | −4.32 | 2.93E-05* | 0.030* | −2.28 | 0.026* | 0.32 | −1.78 | 0.078 | 0.41 | -- | 0.0062* | 0.085 |
ILMN_1805345 | MOSPD3 | −4.26 | 3.73E-05* | 0.030* | −1.57 | 0.12 | 0.49 | −0.52 | 0.60 | 0.86 | -- | 0.18 | 0.47 |
ILMN_2108823 | FZD7 | −4.24 | 4.06E-05* | 0.030* | −2.10 | 0.039* | 0.32 | −1.13 | 0.26 | 0.86 | -- | 0.034* | 0.23 |
ILMN_1705900 | ATXN10 | −4.24 | 4.07E-05* | 0.030* | −0.46 | 0.65 | 0.74 | 0.49 | 0.63 | 0.86 | -+ | 0.90 | 0.97 |
ILMN_2282959 | DNA2 | −4.24 | 4.08E-05* | 0.030* | −1.76 | 0.082 | 0.48 | −0.19 | 0.85 | 0.89 | -- | 0.24 | 0.49 |
ILMN_3240883 | SNORA11C | −4.21 | 4.55E-05* | 0.030* | −0.50 | 0.62 | 0.73 | −0.67 | 0.51 | 0.86 | -- | 0.41 | 0.60 |
ILMN_1760479 | MOS | −4.20 | 4.71E-05* | 0.030* | −1.19 | 0.24 | 0.51 | −0.98 | 0.33 | 0.86 | -- | 0.14 | 0.43 |
ILMN_1657478 | MAGEL2 | −4.19 | 4.97E-05* | 0.030* | −0.99 | 0.33 | 0.64 | −1.39 | 0.17 | 0.68 | -- | 0.089 | 0.37 |
ILMN_1755920 | LOC158381 | −4.19 | 4.98E-05* | 0.030* | −0.76 | 0.45 | 0.67 | −1.63 | 0.10 | 0.48 | -- | 0.079 | 0.36 |
ILMN_1815392 | ACTRT1 | −4.15 | 5.77E-05* | 0.032* | −1.41 | 0.16 | 0.49 | −1.76 | 0.080 | 0.41 | -- | 0.025* | 0.21 |
ILMN_1747716 | ALDOB | −4.14 | 5.85E-05* | 0.032* | −1.29 | 0.20 | 0.49 | −0.60 | 0.55 | 0.86 | -- | 0.22 | 0.49 |
ILMN_1761598 | PRDM9 | −4.08 | 7.53E-05* | 0.039* | −1.88 | 0.064 | 0.44 | −0.52 | 0.61 | 0.86 | -- | 0.13 | 0.43 |
ILMN_2253246 | DNAJC28 | −4.06 | 8.02E-05* | 0.039* | −1.15 | 0.25 | 0.52 | −0.34 | 0.73 | 0.86 | -- | 0.34 | 0.54 |
ILMN_2359710 | PTP4A3 | −4.04 | 8.78E-05* | 0.040* | −0.30 | 0.77 | 0.81 | 0.40 | 0.69 | 0.86 | -+ | 0.88 | 0.97 |
ILMN_1798076 | HOXD3 | −4.03 | 8.93E-05* | 0.040* | −0.33 | 0.74 | 0.80 | −0.68 | 0.50 | 0.86 | -- | 0.46 | 0.61 |
ILMN_1808272 | KCNJ10 | −4.02 | 9.44E-05* | 0.040* | −1.31 | 0.19 | 0.49 | −0.90 | 0.37 | 0.86 | -- | 0.14 | 0.43 |
ILMN_2268381 | RRBP1 | −4.01 | 9.93E-05* | 0.041* | −1.19 | 0.24 | 0.51 | 1.77 | 0.079 | 0.41 | -+ | 0.47 | 0.61 |
ILMN_1696488 | FGF23 | −3.97 | 0.00011* | 0.045* | −0.96 | 0.34 | 0.64 | 0.19 | 0.85 | 0.89 | -+ | 0.68 | 0.80 |
ILMN_1792885 | CTSC | −3.94 | 0.00013* | 0.047* | −0.036 | 0.97 | 0.97 | −1.15 | 0.25 | 0.86 | -- | 0.34 | 0.54 |
ILMN_2214734 | FRRS1 | −3.94 | 0.00013* | 0.047* | −2.23 | 0.029* | 0.32 | −0.18 | 0.86 | 0.89 | -- | 0.15 | 0.43 |
ILMN_3305849 | LOC728431 | −3.93 | 0.00013* | 0.047* | −0.70 | 0.49 | 0.67 | −0.70 | 0.49 | 0.86 | -- | 0.33 | 0.54 |
ILMN_2387328 | C9orf84 | −3.92 | 0.00014* | 0.047* | −0.34 | 0.73 | 0.80 | −2.00 | 0.047* | 0.41 | -- | 0.071 | 0.36 |
ILMN_1749834 | SMIM1 | −3.91 | 0.00014* | 0.047* | −3.00 | 0.0037* | 0.15 | 0.36 | 0.72 | 0.86 | -+ | 0.16 | 0.43 |
ILMN_1794780 | SHARPIN | −3.89 | 0.00016* | 0.047* | −0.76 | 0.45 | 0.67 | −0.39 | 0.70 | 0.86 | -- | 0.45 | 0.61 |
ILMN_1762319 | SLC43A3 | −3.88 | 0.00016* | 0.047* | −1.51 | 0.13 | 0.49 | −0.50 | 0.62 | 0.86 | -- | 0.20 | 0.48 |
ILMN_2259495 | BID | −3.88 | 0.00016* | 0.048* | 0.74 | 0.46 | 0.67 | −0.43 | 0.67 | 0.86 | +- | 0.93 | 0.97 |
ILMN_1807556 | VWA3A | −3.86 | 0.00017* | 0.048* | −1.29 | 0.20 | 0.49 | −2.79 | 0.0061* | 0.13 | -- | 0.0030* | 0.061 |
ILMN_1778294 | SENP7 | −3.86 | 0.00017* | 0.048* | −0.77 | 0.45 | 0.67 | 0.73 | 0.46 | 0.86 | -+ | 0.88 | 0.97 |
ILMN_1713458 | HBZ | −3.85 | 0.00018* | 0.048* | −0.71 | 0.48 | 0.67 | 0.43 | 0.67 | 0.86 | -+ | 0.95 | 0.97 |
ILMN_2359500 | NCDN | −3.85 | 0.00018* | 0.048* | −0.59 | 0.55 | 0.71 | −0.76 | 0.45 | 0.86 | -- | 0.34 | 0.54 |
ILMN_1803941 | TBC1D15 | 3.83 | 0.00019* | 0.0498* | −0.63 | 0.53 | 0.71 | −0.27 | 0.79 | 0.89 | -- | 0.56 | 0.69 |
ILMN_1753627 | DOLK | −3.82 | 0.00020* | 0.0499* | −0.69 | 0.49 | 0.67 | 0.54 | 0.59 | 0.86 | -+ | 0.98 | 0.98 |
ILMN_1813650 | INPP5F | −3.82 | 0.00020* | 0.0499* | −1.49 | 0.14 | 0.49 | 0.053 | 0.96 | 0.96 | -+ | 0.41 | 0.60 |
indicates significant at the .05 level.
Symbol from the updated annotations in illuminaHumanv4.db.;
ED= Effect Direction in the replication cohorts.