Table 3.
Top disease and biological function gene categories according to INGENUITY analysis of the 90 “target” genes* with pcor<0.10 in the association analysis of the white non-Hispanic male discovery cohort of n=143 PTSD cases and 28 controls.
| Category | Disease/Function Annotation |
p | pcor** | Genes |
|---|---|---|---|---|
| Neurological Disease |
Dysmetria | 4.5×10−5 | 0.025 | PRNP, SPRN |
| Ataxia | 7.4×10−5 | 0.025 |
ATXN10,BID,KCNJ10 MOS, SLC4A7 |
|
| Neurodegeneration of nervous tissue. |
3.78×10−3 | 0.046 | KCNJ10, MOS, SLC4A7 | |
| Tissue Morphology |
Degeneration of organ of Corti |
7.22×10−5 | 0.025 | CLRN1,KCNJ10,SLC4A7 |
| Quality of Chondrocytes |
8.33×10−5 | 0.025 | FGF18, FGF23, FOSL2 | |
| Neurodegeneration of nervous tissue |
3.78×10−3 | 0.046 | KCNJ10, MOS, SLC4A7 | |
| Connective Tissue Development and Function |
Quality of Chondrocytes |
8.33×10−5 | 0.025 | FGF18, FGF23, FOSL2 |
| Proliferation of Chondrocytes |
2.59×10−3 | 0.046 | FGF18, FGF23, FOSL2 | |
| Abnormal morphology of atlas. |
3.01×10−3 | 0.046 | HOXD3, SKI | |
| Auditory Disease |
Collapse of Reissner’s Membrane |
1.49×10−3 | 0.036 | KCNJ10, SLC4A7 |
| Degeneration of supporting cell layer of inner ear |
5.23×10−4 | 0.046 | CLRN1, SLC4A7 | |
| Usher syndrome 3A | 3.91×10−3 | 0.046 | CLRN1 |
*
The complete list of target genes is presented in Supplementary Table 3.
**
pcor is the Benjamini Hochberg FDR corrected p-value.