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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Cytokine. 2015 Mar 17;73(2):236–244. doi: 10.1016/j.cyto.2015.01.009

Figure 1. Model of IL-6 over-production in MS.

Figure 1

Increased IL-6 promotes inflammatory responses through a number of mechanisms. For example, increased IL-6 production in MS can result in T effector cell resistance to suppression by normal negative feedback signaling induced by IL-10. Increased IL-6 promotes inflammatory responses through a number of other mechanisms.