Table I.
Predictors of CM-specific survival obtained from stepwise Cox regression analysis of selected variables†
| Parameter | Category a | No. | P value | HR (95% CI) |
|---|---|---|---|---|
| Age | >50/≤ 50 | 487/371 | 0.162 | 1.39 (0.88–2.19) |
| Sex | Male/Female | 496/362 | 0.081 | 1.51 (0.95–2.40) |
| Clark level | IV/V/II/III | 459/399 | 0.007 | 2.35 (1.27–4.34) |
| Tumor stage | III and IV/I and II | 149/709 | <0.001 | 3.30 (2.13–5.12) |
| Breslow thickness (mm) | ≥1/<1/mm | 511/347 | 0.006 | 3.59 (1.44–8.92) |
| Ulceration of tumor | Yes/No | 155/681 | <0.001 | 2.74 (1.78–4.23) |
| rs11225163 | CC/CT+TT | 342/516 | 0.004 | 1.86 (1.23–2.82) |
| rs7944031 | AG+GG/AA | 205/653 | 0.012 | 1.81 (1.14–2.87) |
| rs1990330 | CA+AA/CC | 385/473 | 0.016 | 1.67 (1.10–2.54) |
CM = cutaneous melanoma; HR = hazards ratio.
†
Including age, sex, tumor stage, Breslow thickness, SLNB, Clark level, ulceration of tumor and tumor cell mitotic rate.
Genotypes 8 SNPs of three genes (YAP1 (rs11225163, rs12226331, rs12795624, rs7110557, rs11605954 and rs12793501), TEAD1 rs7944031, TEAD4 rs1990330) were included in the stepwise multivariate Cox proportional hazards regression analysis.
a
The “/ category” was used as the reference.