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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mol Neurobiol. 2014 Nov 19;53(1):95–108. doi: 10.1007/s12035-014-8989-x

Fig. 3.

Fig. 3

Overexpression of miR-126 modulates Aβ1-42 toxicity and the neuroprotective effects of BDNF in cortical neurons. (a) LDH assays show that overexpression of miR-126 increases the toxic effects of Aβ1-42 and that BDNF (10 ng/ml) protects against Aβ1-42 toxicity in both virus control and miR-126 transduced neurons, and that the neuroprotective effects of BDNF are inhibited in neurons that express trkB siRNAs. *: p < 0.05 comparing treated to untreated condition. #: p < 0.05 comparing Syn.miR-126 to Syn.GFP controls. (b) Western blots demonstrating >75% downregulation of trkB in trkB-siRNA expressing neurons. *: p < 0.05 comparing si-trkB+ to si-trkB− condition.