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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mol Neurobiol. 2014 Nov 19;53(1):95–108. doi: 10.1007/s12035-014-8989-x

Fig. 5.

Fig. 5

Overexpression of miR-126 modulates IGF-1/AKT/GSK-3β and ERK signaling in STS and IGF-1 treated neurons. Quantification of Western blots (a) shows that IRS-1 (b), AKT, pAKT, ERK, pERK, GSK-3β, and pGSK-3β (c) are downregulated in miR-126 overexpressing cells when compared to virus-treated controls. In addition, the pAKT/AKT, pERK/ERK and pGSK-3β/GSK-3β ratios are increased, and the pGSK-3β/GSK-3β ratios decreased in STS/IGF-1 treated and miR-126 transduced cells. Data are plotted as relative percent expression to untreated controls. *: p < 0.05 comparing treated to untreated condition. #: p < 0.05 comparing ratios for Syn.miR-126 to ratios of Syn.GFP controls.