Table 4. Analysis of Allelic Association of SNP rs9943582with Overall CAD and CAD without LVSD.

Cohort (n, case/control)	Count of Genotype in cases			Count of Genotype in controls			Freq _A(case/control)	Observed*		Adjust †		Empirical ‡	Corrected ‖
								P-obs	OR (95%CI)	P-adj	OR (95%CI)	P-emp	P-cor
	AAA	AAG	GGG	AAA	AAG	GGG
Overall CAD
Entire cohort (1,751/1,022)	148	653	950	74	382	566	0.27/0.26	0.34	1.06 (0.94–1.20)	0.22	1.08 (0.95–1.23)	0.35	-
Male(1,056/608)	80	382	594	49	223	336	0.26/0.26	0.64	0.96 (0.82–1.13)	0.94	0.99 (0.84–1.17)	0.65	0.87
Female (695/414)	68	271	356	25	159	230	0.29/0.25	0.04	1.23 (1.00–1.49)	0.05	1.22 (1.00–1.49)	0.04	0.08
Hypertension (1,030/525)	92	361	577	40	183	302	0.27/0.25	0.28	1.10 (0.93–1.30)	0.23	1.01 (0.84–1.22)	0.30	0.48
Non-hypertension (721/497)	56	292	373	34	199	264	0.28/0.27	0.72	1.03 (0.86–1.24)	0.91	1.11 (0.93–1.32)	0.75	0.92
CAD with normal LVEF
Entire cohort (1046/1022)	76	382	588	74	382	566	0.26/0.26	0.77	0.98 (0.85–1.13)	0.95	0.99 (0.86–1.15)	0.85	-
Male(634/608)	39	231	364	49	223	336	0.24/0.26	0.25	0.90 (0.75–1.08)	0.36	0.92 (0.76–1.11)	0.25	0.44
Female(412/414)	37	151	224	25	159	230	0.27/0.25	0.34	1.11 (0.89–1.39)	0.35	1.11 (0.89–1.39)	0.34	0.56
Hypertension(613/525)	44	218	351	40	183	302	0.25/0.25	0.96	1.00 (0.83–1.22)	0.91	1.01 (0.83–1.23)	1.00	0.99
Non-hypertension(433/497)	32	164	237	34	199	264	0.26/0.27	0.72	0.96 (0.78–1.18)	0.81	0.97 (0.79–1.20)	0.75	0.92

Freq _A: Frequency of A allele. LVSD: left ventricle systolic dysfunction, LVEF: left ventricle eject fraction.

*Uncorrected P value and odds ratio (OR) using Chi-square tests with Pearson’s 2×2.

^†Adjusted P value by multivariate logistic regression analysis for potential confounders including age, gender, smoking, hypertension, diabetes mellitus and lipid concentrations (Tch, TG, HDL-c and LDL-c).

^‡ Empirical P values were calculated using 100,000 Monte Carlo simulations

^‖Multiple testing was adjusted by Bonferroni correction