Table 5. Analysis of Allelic Association of SNP rs9943582 with LVSD among the CAD population.

Cohort(n, CAD patients with LVSD / CAD patients with normal LVEF)	Count of Genotype in CAD patients with LVSD			Count of Genotype in CAD patients with normal LVEF			Freq _A(CAD patients with LVSD / CAD patients with normal LVEF)	Observed*		Adjust †		Empirical ‡	Corrected ‖
	AA	AG	GG	AA	AG	GG		P-obs	OR (95%CI)	P-adj	OR (95%CI)	P-emp	P-cor
Entire cohort (431/1046)	52	189	190	76	382	588	0.34/0.26	3.19×10–6	1.50 (1.27–1.78)	6.71×10–5	1.43 (1.20–1.70)	8.00×10–6	-
Male (259/634)	28	98	133	39	231	364	0.30/0.24	0.02	1.31 (1.05–1.65)	0.02	1.32 (1.05–1.66)	0.02	0.04
Female (172/412)	24	91	57	37	151	224	0.40/0.27	1.05×10–5	1.80 (1.38–2.35)	4.85×10–6	1.87 (1.43–2.44)	1.63×10–5	2.10×10–5
Hypertension (263/613)	31	109	123	44	218	351	0.33/0.25	1.18×10–3	1.45 (1.16–1.81)	2.33×10–3	1.48 (1.18–1.86)	1.34×10–5	2.36×10–3
Non-hypertension (168/433)	21	80	67	32	164	237	0.36/0.26	1.20×10–3	1.60 (1.22–2.09)	4.98×10–6	1.63 (1.24–2.14)	1.43×10–5	2.40×10–3

Freq _A: Frequency of A allele. LVSD: left ventricle systolic dysfunction, LVEF: left ventricle eject fraction.

*Uncorrected P value and odds ratio (OR) using Chi-square tests with Pearson’s 2×2.

^†Adjusted P value by multivariate logistic regression analysis for potential confounders including age, gender, smoking, hypertension, diabetes mellitus and lipid concentrations (Tch, TG, HDL-c and LDL-c).

^‡ Empirical P values were calculated using 100,000 Monte Carlo simulations

^‖Multiple testing was adjusted by Bonferroni correction