Table 7. Analysis of Genotypic Association of SNP rs9943582 with overall CAD, CAD without LVSD, and with LVSD among CAD patients.

Cohorts (n, cases vs. controls)	Model	P_obs *	OR (95%CI)	P_adj †	OR(95%CI)	P_emp ‡
All CAD(1,751 vs. 1,022)	Dominant	0.57	1.04 (0.90–1.22)	0.35	1.08 (0.92–1.27)	0.58
	Recessive	0.26	1.18 (0.89–1.58)	0.27	1.19 (0.88–1.60)	0.28
	Additive	0.51	n.a	0.23	1.14 (0.97–1.31)	0.51
CAD with normal LVEF(1,046 vs. 1,022)	Dominant	0.70	0.97 (0.81–1.15)	0.88	0.99 (0.82–1.18)	0.72
	Recessive	0.98	1.00 (0.72–1.40)	0.92	1.02 (0.72–1.43)	1.00
	Additive	0.92	n.a	0.94	1.00 (0.86–1.15)	0.92
CAD with LVSD (431 vs. 1,046)	Dominant	8.98×10–4	1.48 (1.15–1.81)	1.80×10–5	1.55 (1.23–1.95)	4.66×10–4
	Recessive	0.02	1.56 (1.07–2.29)	0.02	1.59 (1.08–2.34)	0.03
	Additive	1.22×10–3	n.a	8.98×10–5	1.42 (1.19–1.69)	2.12×10–3

P-obs: P value observed, P-adj: P value with adjustment, OR: odds ratio, n.a: no data.

*Uncorrected P value and odds ratio (OR) using Chi-square tests with Pearson’s 2×2

^†Adjusted P value by multivariate logistic regression analysis for potential confounders including age, gender, smoking, hypertension, diabetes mellitus and lipid concentrations (Tch, TG, HDL-c and LDL-c).

^‡ Empirical P values were obtained by performing 100,000 Monte–Carlo simulations.