Table 3.
Univariate and multivariate analyses of prognostic factors in gastric cancer patients
| Variable | Univariate P value |
Multivariate |
||
| HR | 95%CI | P value | ||
| Age (yr) | 0.041 | 0.004 | ||
| ≤ 65 | 1 | |||
| > 65 | 2.323 | 1.299-4.156 | ||
| Sex | 0.299 | |||
| Male | ||||
| Female | ||||
| Resectability | < 0.001 | 0.018 | ||
| R0 | 1 | |||
| R1, R2 | 2.062 | 1.133-3.759 | ||
| Tumor depth | < 0.001 | |||
| T1, T2 | ||||
| T3, T4 | ||||
| Lymph node | < 0.001 | |||
| N0 | ||||
| N1-3 | ||||
| Distant metastasis | < 0.001 | < 0.001 | ||
| M0 | 1 | |||
| M1 | 10.505 | 6.540-16.874 | ||
| Pathological stage | ||||
| I | 1 | |||
| II | < 0.001 | 2.552 | 1.591-4.095 | < 0.001 |
| III | < 0.001 | 4.695 | 3.053-7.220 | < 0.001 |
| IV | < 0.001 | 10.505 | 6.540-16.874 | < 0.001 |
| WBC | 0.002 | |||
| ≤ 11 × 109/L | ||||
| > 11 × 109/L | ||||
| ALB | < 0.001 | |||
| ≥ 35 g/L | ||||
| < 35 g/L | ||||
| PLT | < 0.001 | |||
| ≤ 300 × 109/L | ||||
| > 300 × 109/L | ||||
| CEA | < 0.001 | 0.004 | ||
| ≤ 5 ng/mL | 1 | |||
| > 5 ng/mL | 1.457 | 1.126-1.883 | ||
| Histological type | < 0.001 | |||
| Well | ||||
| Poor | ||||
| Blood loss | < 0.001 | |||
| ≤ 400 mL | ||||
| > 400 mL | ||||
| Operative time | 0.067 | |||
| ≤ 4 h | ||||
| > 4 h | ||||
| Postoperative chemotherapy | 0.479 | |||
| Absent | ||||
| Present | ||||
| Postoperative complications | < 0.001 | 0.002 | ||
| Absent | 1 | |||
| Present | 1.516 | 1.164-1.974 | ||
| PNI | < 0.001 | < 0.001 | ||
| 1 | 1 | |||
| 2 | 1.668 | 1.368-2.035 | ||
| NLR | < 0.001 | 0.656 | ||
| 1 | 1 | |||
| 2 | 1.056 | 0.830-1.343 | ||
| PLR | < 0.001 | 0.113 | ||
| 1 | 1 | |||
| 2 | 1.190 | 0.960-1.475 | ||
| Propensity score | 0.398 | |||
WBC: White blood cell; ALB: Albumin; PLT: Platelet; CEA: Carcino-embryonic antigen; PNI: Prognostic nutritional index; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; HR: Hazard ratio.