Table 1.
Summary of patients with primary hepatic angiosarcoma
| Ref. | n | Age (yr) (median) | Sex (M/F) | Clinical manifestations | Tumor characteristics (n) | Extrahepatic metastasis | Tumor rupture | Treatment | Surgical margin | Survival time |
| Kim et al[10] | 5 | 41-69 (45) | 5/0 | Right upper abdominal pain, leg edema, hemoptysis, ascites, chest discomfort, DOE | Multiple nodules (5) | Spleen (2), lung (1), pericardium (1), bone (1) | 1 | Palliative chemotherapy (4) | / | 86 d (m)1 |
| Yin et al[11] | 7 | 34-71 (52) | 6/1 | Abdominal pain, jaundice, ascites, anemia, chest pain, edema, weight loss | NS | Spleen (1), lung (2), bone (1) | None | Hepatectomy + chemotherapy (3), chemotherapy (2) | NS | 89.9 d (m)1 (13-238 d), of hepatectomy + chemotherapy: 94 d (m)1 |
| López et al[36] | 2 | 20, 31 | 2/0 | Acute liver failure | Diffuse micronodules (1), multiple nodules (1) | NS | None | Transplantation + chemotherapy (1), Conservative therapy (1) | / | 2 mo, 17 d |
| Egea Valenzuela et al[15] | 2 | 65, 73 | 2/0 | Jaundice, abdominal distension, bleeding tendency | Multiple nodules (2) | None | None | Conservative therapy | / | 36 h, several days |
| Matthaei et al[13] | 5 | 20-80 (56) | 3/2 | NS | Dominant mass (5) | Lung (3), peritoneum (1) | None | Hepatectomy | R0 (4), R (1) | 30 mo (m)1, 1 alive with recurrence (R0), 1 no evidence of recurrence (R0) |
| Yang et al[37] | 1 | 70 | 1/0 | Asymptomatic | Multiple nodules | None | None | Conservative therapy | / | 6 mo |
| Park et al[12] | 6 | 29-80 (59.5) | 5/1 | Abdominal pain, fever, abdominal distension, hematuria, anemia | Dominant mass and/or intrahepatic nodules(6) | Spleen (1) | 3 | TACE (4), TAE (2) | / | 3.5 mo (m)1 |
| Bruegel et al[14] | 7 | 51-78 (65) | 4/3 | Abdominal pain, weight loss, fatigue, jaundice | Dominant mass (1), multiple nodules (6) | Spleen (1), bone (3), lung (2), cerebellum (1) retroperitoneum (2) | 1 | Hepatectomy + chemotherapy(1), hepatectomy (1), chemotherapy(4) | NS | 16 mo (m)1 |
1
Represents median survival time. DOE: Dyspnea on exertion; NS: Not specified; R0: No residual tumor; R1: Microscopic residual tumor; M: Male; F: Female.