Table 1. Characteristics of pregnant women and ARTs for perinatal HIV prevention according to study.
| Variable | PHPT-1 | PHPT-2 | PHPT-2 OPEN Label | PHPT-2 PK | PHPT-5 | Total |
|---|---|---|---|---|---|---|
| Number of women with at least 1 VL sample | 1,398 | 1,784 | 128 | 26 | 423 | 3,759 |
| Characteristics of pregnant women | ||||||
| Gestational age at enrollment (weeks) | ||||||
| Median | 28.0 | 31.0 | 38.4 | 33.9 | 29.0 | 29.6 |
| Interquartile range | 27.7 to 28.2 | 30.1 to 33.1 | 36.5 to 40.0 | 31.3 to 37.3 | 28.0 to 30.0 | 28.0 to 31.6 |
| CD4 at enrollment (cell count/ mm3) | ||||||
| Median | 360 | 376 | 368 | 454 | 458 | 385 |
| Interquartile range | 240 to 500 | 247 to 528 | 243 to 542 | 270 to 582 | 368 to 576 | 260 to 526 |
| Gestational age at delivery (weeks) | ||||||
| Median | 39.0 | 38.6 | 38.6 | 39.4 | 38.7 | 38.7 |
| Interquartile range | 38.0 to 40.0 | 37.9 to 39.6 | 37.0 to 40.0 | 38.1 to 40.6 | 37.8 to 39.7 | 37.9 to 39.7 |
| Type of delivery | ||||||
| 1) emergency C/section | 141 (10%) | 265 (15%) | 21 (16%) | 7 (27%) | 0 (0%) | 434 (11%) |
| 2) planned C/section | 111 (8%) | 105 (6%) | 9 (7%) | 3 (11%) | 59 (14%) | 287 (8%) |
| 3) vaginal delivery | 1,146 (82%) | 1,414 (79%) | 98 (77%) | 16 (62%) | 364 (86%) | 3,038 (81%) |
| Maternal treatment | ||||||
| ZDV during pregnancy | 1,387 (>99%) | 1,784 (100%) | 73 (57%) | 23 (88%) | 423 (100%) | 3,690 (98%) |
| ZDV duration (days) | ||||||
| Median | 57 | 67 | 0 | 52 | 71 | 65 |
| Interquartile range | 30 to 79 | 52 to 77 | 0 to 11.5 | 30 to 61 | 60 to 78 | 39 to 77 |
| LPV during pregnancy | - | - | - | - | 145 (4%) | 145 (4%) |
| LPV duration (days) | ||||||
| Median | - | - | - | - | 69 | 69 |
| Interquartile range | - | - | - | - | 55 to 77 | 55 to 77 |
| NVP at onset of labor | - | 1407 (79%) | 110 (86%) | 26 (100%) | 133 (31%) | 1,676 (45%) |
| ZDV loading dose at onset of labor | 1,336 (96%) | 1,777 (>99%) | 119 (93%) | 26 (100%) | 410 (97%) | 3,668 (98%) |
| Infant treatment | ||||||
| ZDV prophylaxis | 1,381 (99%) | 1,779 (>99%) | 127 (99%) | 26 (100%) | 420 (99%) | 3,733 (99%) |
| ZDV duration (days) | ||||||
| Median | 41 | 11 | 44 | 7 | 7 | 11 |
| Interquartile range | 3 to 42 | 10 to 14 | 41 to 48 | 6 to 7 | 7 to 7 | 7 to 41 |
| Postnatal NVP (infants) | - | 729 (41%) | 134 (97%) | 26 (100%) | 275 (65%) | 1,154 (31%) |
| Perinatal NVPa | - | 1,424 (80%) | 126 (98%) | 26 (100%) | 276 b (65%) | 1,852 (49%) |
a sdNVP either in the woman at onset of labor, in the infant or in both
b only in women who did not receive LPV/r