Table 4. The univariate and multivariable analyses of the HIV intra-partum transmission model using data from 3,707 HIV-1-infected mothers enrolled in the PHPT-1, PHPT-2, and PHPT-5 studies.
| Predictors | Logit coefficient(95%CI) | Odds ratio(95%CI) | RSE (%) a | BIC b |
|---|---|---|---|---|
| Univariate analysis | ||||
| Baseline model | -3.29 (-3.43, -3.15) | - | 2 | 968.77 |
| ZDV duration (weeks) | -0.049 (-0.09, -0.01) | 0.95 (0.91, 0.99) | 46 | 956.07 |
| VL at delivery (log10 copies/mL) | 0.17 (0.08, 0.26) | 1.18 (1.08, 1.30) | 26 | 953.04 |
| CD4 (per 100 cell count) | -0.18 (-0.27, -0.09) | 0.83 (0.77, 0.91) | 25 | 942.79 |
| Premature labor | 0.81 (0.30,1.32) | 2.25 (1.35, 3.75) | 32 | 957.50 |
| Perinatal NVP | -1.10 (-1.53, -0.67) | 0.33 (0.22, 0.51) | 20 | 943.94 |
| Multivariable analysis | ||||
| Model 1 | 926.61 | |||
| Perinatal NVP | -0.97 (-1.44, -0.50) | 0.38 (0.24, 0.61) | 25 | |
| CD4 | -0.22 (-0.33, -0.12) | 0.80 (0.72, 0.88) | 23 | |
| Model 2 | 916.58 | |||
| Perinatal NVP | -1.13 (-1.58, -0.68) | 0.32 (0.21, 0.51) | 21 | |
| CD4 | -0.23 (-0.33, -0.12) | 0.80 (0.72, 0.88) | 16 | |
| VL at delivery | 0.42 (0.29, 0.55) | 1.52 (1.34, 1.74) | 23 | |
| Model 3 | 922.80 | |||
| Perinatal NVP | -1.15 (-1.62, -0.68) | 0.32 (0.20, 0.51) | 21 | |
| CD4 | -0.153 (-0.25, -0.05) | 0.86 (0.78, 0.95) | 33 | |
| VL at delivery | 0.634 (0.51, 0.76) | 1.88 (1.67, 2.13) | 10 | |
| ZDV duration | 0.0001 (-0.0072, 0.0073) | 1.00 (0.99, 1.01)) | 3.67e+004 | |
| Final model c | 916.61 | |||
| Perinatal NVP | -1.13 (-1.58, -0.68) | 0.32 (0.21, 0.51) | 21 | |
| CD4 | -0.23 (-0.34, -0.13) | 0.79 (0.72, 0.88) | 22 | |
| VL at delivery | 0.36 (0.23, 0.50) | 1.44 (1.26, 1.64) | 19 | |
| Premature labor | 0.86 (0.31, 1.41) | 2.37 (1.37, 4.10) | 32 |
aRSE%, relative standard error (standard error of estimate / estimate*100)
b Bayesian Information Criterion
c Random effect of individuals: η~N(0,0.732)