Table 1:
EDH-mediated responses and diabetes
| Species | Model/Duration of diabetes | Blood vessels | EDH responses | Mechanisms |
|---|---|---|---|---|
| Type 1 diabetes | ||||
| SD rat | STZ/10 w | Mesenteric (4) | Decrease | Did not involve a decrease in channel expression, which may be due to a disruption of the downstream pathways of IKCa and SKCa channels |
| Wistar rat | STZ/12 w | Mesenteric (6) | Decrease | Reduction in cAMP |
| Wistar rat | STZ/8 w | Retinal arteriole (24) | Decrease | Not determined |
| Wistar rat | STZ/10 w | Carotid (25) | Decrease | May be due to changes to ATP-sensitive K+ channels on smooth muscles |
| Mice | STZ/10 w | Mesenteric (26, 27) | Decrease | May be due to LPC-induced inhibition of EDH |
| Mice | STZ/17-18 w | Thoracic aorta (37) | Increase | Not determined |
| SD rat | STZ/8 w | Thoracic aorta (38) | Increase | Not determined |
| SD rat | STZ/12 w | Femoral and mesenteric (39) | Increase | Not determined |
| Human | Pregnant women | Subcutaneous (7) | Preserved | - |
| Type 2 diabetes | ||||
| Rat | OLEFT | Mesenteric (43) | Decrease | Defect cAMP/PKA signalling and endothelial K+ channel |
| Zucker Diabetic | Mesenteric (44) | Decrease | - | |
| Fatty rat | Sciatic nerve epineural arterioles (47, 48) | |||
| Goto-Kakizaki rat | Mesenteric (45) | Decrease | May be due to changes to ATP-sensitive K+ channels on smooth muscles | |
| Mice | db/db | mice Coronory (46) | Decrease | - |
| Mice | db/db | mice Mesenteric (49) | Increase | - |
| Rabbit | Alloxan | Renal (50) | Preserved | - |