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. Author manuscript; available in PMC: 2015 Sep 25.
Published in final edited form as: Nat Commun. 2015 Mar 25;6:6644. doi: 10.1038/ncomms7644

Figure 3. MER130 members function as enhancers but may not occupy open chromatin.

Figure 3

(a) Maximum neocortex p300 ChIP-seq intensity (x-axis) plotted against average fold activity relative to the empty vector when transfected into dissociated cortical neurons (y-axis) for each MER130 instance tested. (b) Average DNase-seq intensity across two mouse E14.5 whole brain replicates (x-axis) plotted against same y-axis as (a) for the same set of MER130 instances. In both panels, MER130 elements enriched for the p300 signal in black (n = 23) and depleted for the p300 signal in gray (n = 7). t-test. *p-value < 0.05; **p-value < 0.01.