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. 2015 May 20;35(20):7878–7891. doi: 10.1523/JNEUROSCI.2179-14.2015

Figure 3.

Figure 3.

Hearing impairment in mature (>P28) DTR mice after injection of DT. ABRs were measured in mature mice at several times after injection of DT (25 ng/g). DTR mice have normal ABR thresholds before DT injection (DTR control). Hearing loss is not apparent at 1 dpi in DTR mice. ABR thresholds are highly elevated by 3 dpi. By 5 dpi, mature mice did not respond to any stimulus frequency (↑), whereas these same mice have normal hearing thresholds before DT injection. WT mice have normal hearing 5 dpi (WT control). Data are mean ± SD, n = 3–5 per group. Statistical analyses (two-way ANOVA followed by Bonferroni post hoc tests) yielded highly significant (p < 0.001) effect of groups and frequency as well as the interaction term due to significant hearing loss at 3 and 5 dpi in DTR mice. Difference between 1 d DTR animals and control groups is not significant (p > 0.10). Differences between 3 and 5 d DTR animals and all other groups are all highly significant at all frequencies (p < 0.01). Difference between 3 and 5 dpi DTR animals is significant at 16 kHz (p < 0.05).