Figure 4.

Relationship between ΔBMI and amygdala response to the taste of palatable food. Predicted correlations (ROI analysis) between ΔBMI and BLA response to M > T at the sated scan that interact with genotype, with peaks at x, y, z = 39, −1, −23 (A) and x, y, z = 30, −7, −20 (B). Scatterplots show the relationship between ΔBMI and parameter estimates at the peak voxel in that region for A1+ and A1−. Note that, whereas there appears to be a negative correlation between BLA response and ΔBMI in A1+, this relationship does not meet criteria for statistical significance outside of the peak voxel. Color bars depict t-values. C, Histogram shows group differences in the relationship between ΔBMI and BLA response to M > T Sated. Bootstrapping was used to depict the observed sample distribution of the correlation coefficient separately for A1+ and A1−. Density on the y-axis reflects the likelihood of observing a particular correlation coefficient value (x-axis) and is higher if estimated correlations within groups are more homogenous. Lesser distribution overlap corresponds to stronger group differences.