Table 2.

Biophysical properties of TTX-S and TTX-R I_Na components of EGFP-positive DRG neurons^a

	TTX-S INa	TTX-R INa
V1/2,act (mV)	−20.6 ± 0.3	−6.7 ± 0.2*
ka (mV)	4.0 ± 0.2	3.7 ± 0.2
V1/2,inact (mV)	−60.7 ± 1.1	−25.3 ± 0.6*
ki (mV)	−8.9 ± 0.9	−6.9 ± 0.6

^aSummary of sodium channel properties of EGFP-positive DRG neurons from Scn10a-EGFP mice. TTX-R I_Na were recorded in the presence of 3 μm TTX, and TTX-S I_Na were derived from subtracting the TTX-R component of I_Na from total I_Na, recorded before application of TTX. All voltage protocols and equations used to calculate V_1/2 and k values are detailed in Materials and Methods. Complete activation curves were constructed from recordings of 28 EGFP-positive DRG neurons, and the inactivation protocol was successfully applied to 23 EGFP-positive DRG neurons. Data are mean ± SEM.

*p < 0.001 (Student's t test).