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. 2015 May 20;9:117. doi: 10.3389/fnbeh.2015.00117

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Copyright © 2015 Grüter, Wiescholleck, Dubovyk, Aliane and Manahan-Vaughan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MK801-treatment alters GABA receptor and N-methyl-D-aspartate receptor (NMDAR) subunit expression in the hippocampus and prefrontal cortex. Bar charts represent receptor expression in the hippocampal subregions (CA1, CA2/3, CA4, dentate gyrus:DG), and in the prefrontal cortex (PFC) 4 weeks after MK801-treatment (derived from densitometry of the DAB-labeled immunohistochemistry). In MK801-treated animals, (A) GABA(A) expression was reduced in the prefrontal cortex but unchanged in the hippocampus, whereas GABA(B) expression (B) was significantly increased in both the dentate gyrus and prefrontal cortex compared to vehicle-treated controls. Whereas GluN1 (C) and GluN2A (D) expression was unaffected by MK801-treatment, GluN2B expression (E) was significantly increased in the dentate gyrus compared to vehicle-treated controls *p < 0.05.