Table 4.
In vivo inhibitory activities of the five compounds against S. pneumoniae NCTC7466.
| Compound | Mean survival of mice ± SEM (hours) | P-valueb | Dose (mg/kg) | cc50 mM |
|---|---|---|---|---|
| Untreated controla | 28.8 ± 1.25 | |||
| 5′-(Methylthio)-5′-deoxyadenosine | 49.5 ± 3.93 | 0.0062 | 97.2 | >16 (336) |
| Octanal, 2-(2, 4-dinitrophenyl) hydrazone | 42.1 ± 4.1 | 0.0053 | 50.4 | >4 (<16) |
| Deoxyshikonin | 50.6 ± 4.1 | <0.0001 | 44.5 | 4.68 (<16) |
| Kavahin | 71.1 ± 7.1 | <0.0001 | 89.7 | >8 (193) |
| Dodecylgallate | 60.2 ± 7.3 | 0.0005 | 55.3 | 6.45 (29.5) |
a
Infected mice were treated with 1% DMSO (vol/vol) and 0.2% Tween 20 (vol/vol) in water.
b
Unpaired t-test (vs. untreated control). P < 0.05 was considered significant.