Skip to main content
. Author manuscript; available in PMC: 2015 Jun 18.
Published in final edited form as: Biol Chem. 2015 May;396(5):415–444. doi: 10.1515/hsz-2015-0102

Figure 6. Redox-sensing by the MarR/OhrR-family regulator SarZ of S. aureus.

Figure 6

In S. aureus, the MarR/OhrR-family regulator SarZ functions as global regulator for ROS detoxification, antibiotic resistance and virulence functions and contains a single Cys13 required for redox-sensing. The DNA-binding activity of SarZ was shown to be reversibly redox-regulated by S-thiolation with a synthetic benzene thiol (Poor et al, 2009) and by cysteine phosphorylation via the eukaryotic-like serine/threonine kinase (Stk1) and phosphatase (Stp1)(Sun et al, 2012). SarZ controls genes for the ohr peroxiredoxin, cell surface proteins, antibiotic resistance efflux pumps (norB, tet38), amino acid, sugar, fatty acid and anaerobic metabolism (pflAB). Examples for SarZ regulon genes are listed in Table 3.