Table 3. The MarR-type redox-regulators of the OhrR/SarA/DUF24-subfamilies.

Redox sensor	Organism	Signal	Redox-sensing mechanism	Regulon genes	Regulon functions	References
OhrR	Bacillus subtilis	ROOH NaOCl	C15*-SSB	ohrA	2-Cys-peroxiredoxin	Fuangthong et al, 2001 Lee et al, 2007 Chi et al, 2011
OhrR	Xanthomonas campestris	ROOH	C22*-C127 Intermolecular disulfide	ohrA	2-Cys-peroxiredoxin	Panmanee et al, 2006 Newberry et al, 2007
MgrA (OhrR)	Staphylococcus aureus	H2O2 ROOH	C12*-SOH C12*-Phosphate	cap5(8) hlgABC, pvl lukED, lukMF-PV hla coa spa splABCDEF nuc lytM, lytN norA, norB tetAB agr, lytRS, arlRS, sarS and sarV	capsule polysaccharides leukotoxins α-hemolysin coagulase, protein A serine proteases nuclease autolysis factors multidrug efflux pumps virulence regulators	Luong et al, 2006 Chen et al, 2006 Chen et al, 2009 Sun et al, 2012
SarZ (OhrR)	Staphylococcus aureus	H2O2 ROOH	C13*-SOH C13*-SSR C13*-Phosphate	ohr acs, pflAB pckA argGH, ilvD, lysC, hisC fabG gntRK, lacD, malA, treC, isdC, epiEF, lrgB, efb, fib, tcaA norB, tet38 nuc	2-Cys peroxiredoxin pyruvate metabolism amino acid metabolism fatty acid synthesis sugar metabolism cell surface proteins drug efflux pumps exonuclease	Ballal et al, 2009 Chen et al, 2009 Poor et al, 2009 Sun et al, 2012
SarA (MarR)	Staphylococcus aureus	H2O2 diamide	C9* redox- sensitive C9*-Phosphate	sodA trxB hla spa fnb cna sec icaRA, bap ssp, aur rot, agr, sarS, sarV, sarT	superoxide dismutase thioredoxin reductase α-hemolysin protein A fibronectin-binding collagen-binding enterotoxin C biofilm formation proteases virulence regulators	Ballal & Manna, 2009 Ballal & Manna, 2010 Sun et al, 2012
MosR (OhrR)	Mycobacterium tuberculosis	H2O2 ROOH	C10-C12 intramolecular disulfide	rv1050 mosR	exported oxidoreductase MarR/OhrR-like repressor	Brugarolas et al, 2012
RosR (MarR)	Corynebacterium glutamicum	H2O2	C92* redox sensitive	rosR narKGHJI cg2329 cg3085 cg1848 cg3084 cg1150 cg1850 cg1426 cg1322	MarR-type repressor nitrate/nitrite transporter luciferase-like monooxygenases flavin-containing monooxygenases FMN reductases glutathione-S- transferases polyisoprenoid-binding protein	Bussmann et al, 2010
HypR (MarR/DUF24)	Bacillus subtilis	Quinone Diamide NaOCl	C14*-C49 intermolecular disulfide	hypR hypO	MarR/DUF24-activator FMN-nitroreductase	Palm et al, 2012
YodB (MarR/DUF24)	Bacillus subtilis	Quinone Diamide NaOCl	C6*-C101 intermolecular disulfide	yodB yodC azoR1 catDE	MarR/DUF24-repressor nitroreductase azoreductase dioxygenase	Leelakriangsak et al, 2008 Chi et al, 2010a Chi et al, 2010b
CatR (MarR/DUF24)	Bacillus subtilis	Quinone Diamide NaOCl	C7*redox- sensitive	catDE	dioxygenase	Chi et al, 2010b
QsrR (MarR/DUF24)	Staphylococcus aureus	Quinone	C5*-S-alkylation	SAV0340 (azoR1) SAV2033 (yodC) SAV0338 SAV2522 (catE)	FMN-dependent quinone reductase nitroreductase glyoxalase dioxygenase	Ji et al, 2013
QorR (MarR/DUF24)	Corynebacterium glutamicum	Quinone Diamide	C17*-C17 Intermolecular disulfide	qorA	quinone reductase	Ehira et al, 2009a