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. 2015 Jan 16;54(3):289–297. doi: 10.3109/0284186X.2014.991045

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© 2015 Informa Healthcare

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Figure 4. — Rat brain histology: The left column shows HE stained axial tissue samples at depth 3 mm (z = 3). The electrodes were deployed orthogonal to the sample plane. White arrows point at selected electrode marks. The right column shows magnifications, including overlays of calculated iso-field lines at selected intensities (in V/cm). Samples are NF stained (neurofilament), HE stained and GFAP stained (glial filament), from top to bottom. GFAP stained coronal tissue sample: Generally the tissue is recovered and scar tissue (reactive gliosis) is seen only in close proximity of the electrode (arrow) where the electric field intensity is very high. In the superior part of the brain there is a slightly diffuse reactive gliosis connected to surgery of the brain dura and penetration of the device.