Figure 1.

Schematic representation of data collected in patients with mild cognitive impairment. From top to bottom: (1) Functional MRI (fMRI) collected during an associative face-name encoding task; (2) hippocampal volume (HV), (3) Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes score (CDR_SB); and (4) amyloid-β PET imaging (Aβ). Functional MRI: shows brain activity depicted in yellow/red projected on an inflated brain for right hemisphere, midline and a sagittal slice with the hippocampus, shown at P < 0.001 (uncorrected) from the contrast novel-repeated at baseline (BL), 3, 6, 12, 18, 24 and 36 months (m). Hippocampal volume: shows the anatomical T₁-weighted scans of one MCI patient, analysed with the longitudinal FreeSurfer pipeline and used to estimate grey matter volume of the hippocampus (shown in yellow). MMSE/CDR_SB: shows time points of neuropsychological examination matched to the closest MRI visit. Amyloid-β: shows an example of an Aβ+ PET scan, using PiB. PET data acquisition was collected near baseline (4 months) and used to identify Aβ− and Aβ+ patients with MCI. Below each visit number of observations (n) are shown in grey for at each visit separately for functional MRI, hippocampal volume, CDR_SB and the amyloid-β PET scans.