Table 1.
Demographics, baseline and final assessment
| Aβ− MCI | Aβ+ MCI | |||
|---|---|---|---|---|
| Baseline assessment | n | 16 | 17 | |
| gender (% female) | 19 | 24 | chi = 0.57 | |
| age | 72 ± 1.91 | 74 ± 2.03 | P = 0.57 | |
| years of education | 16 ± 0.64 | 17 ± 0.51 | P = 0.21 | |
| APOE (% ε4 carriers) | 38 | 50 | chi = 0.58a | |
| Amyloid-β (PiB/FLR) | 1.1 ± 0.02 | 1.6 ± 0.05 | P < 0.001b | |
| CDR | 0.5 | 0.5 | – | |
| LMIIa | 7.6 ± 1.32 | 5.0 ± 0.89 | P = 0.12 | |
| MMSE | 27.9 ± 0.33 | 26.9 ± 0.47 | P = 0.11 | |
| Hippocampal fMRI | 0.15 ± 0.037 | 0.31 ± 0.058 | P = 0.024 | |
| Hippocampal volume | 7197 ± 281 | 6287 ± 238 | P = 0.019 | |
| CDRSB | 1.3 ± 0.16 | 1.9 ± 0.25 | P = 0.055 | |
| Final assessment | LMIIa | 10.25 ± 1.48 | 6.1 ± 1.6 | P = 0.064 |
| MMSE | 27.9 ± 0.51 | 26.2 ± 0.54 | P = 0.037 | |
| Hippocampal fMRI | 0.10 ± 0.038 | 0.27 ± 0.068 | P = 0.039 | |
| Hippocampal volume | 7045 ± 285 | 6009 ± 273 | P = 0.013 | |
| CDRSB | 1.5 ± 0.22 | 3.2 ± 0.41 | P = 0.001 |
APOE = carriers of apolipoprotein E (APOE) ε4 allele; LMIIa = the Wechsler Memory Scale-Revised Logical Memory Test delayed recall; MMSE = Mini-Mental State Examination; CDRSB = Clinical Dementia Rating Sum of Boxes score; PiB = Pittsburg Compound-B (PiB) retention in neocortical regions of interest comprised of frontal, lateral temporal and retrosplenial (FLR) cortex.
P-values denote t-test or chi-squares test.
aAPOE genotype available in 23 MCIs.
bUsed to catogorize Aβ−/Aβ+ MCI groups.