Table 1.
Parameters | Control | p1 | p2 | NAFLD with normal transaminases | NAFLD with elevated transaminases | p3 | p |
---|---|---|---|---|---|---|---|
(n = 28) | (n = 37) | (n = 26) | |||||
Age, years | 53.57 ± 7.16 | - | - | 53.27 ± 8.39 | 51.5 ± 10.92 | - | NS |
Duration of T2D, years | 5.0 ± 2.81 | - | - | 5.97 ± 3.88 | 8.54 ± 5.57 | - | NS |
BMI, kg | 31.15 ± 3.0 | 0.028 | <0.001 | 34.46 ± 5.64 | 40.35 ± 5.63 | <0.001 | <0.001 |
ALT, U | 25.03 ± 7.26 | NS | <0.001 | 28.93 ± 6.15 | 64.96 ± 14.99 | <0.001 | <0.001 |
AST, U/L | 23.91 ± 6.11 | NS | <0.001 | 26.6 ± 5.71 | 55.8 ± 11.91 | <0.001 | <0.001 |
FPI, μIU/ml | 11.21 ± 3.58 | 0.001 | <0.001 | 18.27 ± 8.14 | 20.61 ± 8.56 | NS | <0.001 |
FPG, mmol/l | 7.80 ± 1.41 | - | - | 8.67 ± 3.25 | 9.48 ± 3.14 | - | NS |
HOMA-IR | 3.86 ± 1.41 | <0.001 | <0.001 | 6,86 ± 3.21 | 8.23 ± 2.85 | NS | <0.001 |
TC, mmol/l | 5.68 ± 0.68 | 0.004 | <0.001 | 6.24 ± 0.72 | 6.56 ± 0.62 | NS | <0.001 |
TG, mmol/l | 1.83 ± 0,45 | 0,018 | <0,001 | 2,65 ± 1,2 | 3,36 ± 1,55 | NS | <0,001 |
VLDL-C, mmol/l | 0.82 ± 0.2 | 0.005 | <0.001 | 1.25 ± 0.59 | 1.39 ± 0.63 | NS | <0.001 |
HDL-C, mmol/l | 1.66 ± 0.25 | 0.001 | <0.001 | 1.43 ± 0.24 | 1.2 ± 0.26 | 0.002 | <0.001 |
LDL-C, mmol/l | 3.18 ± 0.6 | 0.047 | <0.001 | 3.61 ± 0.69 | 4.07 ± 0.78 | 0.034 | <0.001 |
p - the difference between all study groups calculated using one-way ANOVA
p 1-3 - for pairwise comparisons used Bonferroni Posthoc test
p1 - the difference between the control and normal transaminases groups
p2 - the difference between the control and elevated transaminases groups
p3 - the difference between normal and elevated transaminases groups