Figure 1.

Schematic representations of the modeling methodology.a) The starting point is an experimentally grounded and dynamically characterized GRN Boolean model. Here the FOS-GRN is used, which recovers ten fixed-point attractors representing the cell-types observed during early flower development. b) The Boolean model is transformed into an equivalent continuous dynamical model. A set of rules is applied to the logical propositions of the Boolean model in order to derive a logic-based ODE model in continuous state-space. c) An attractor-wise, gene-wise numerical bifurcation analysis is performed. Because of qualitative changes to the AL induced by increasing parameter values several basins of attraction may merge into one, causing an inevitable cell-fate decision (i.e., an attractor transition).