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. 2015 May 20;5:10442. doi: 10.1038/srep10442

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Regional plot of association results and recombination rates for the (a) 1p36.12, (b) 10p13 and (c) 16q24.1 risk loci. Association results of both genotyped (triangles) and imputed (circles) SNPs in the GWAS samples and recombination rates within the loci at 1p36.12 (a), 10p13 (b) and 16q24 (c). For each plot, −log₁₀ P values (y axis) of the SNPs are shown according to their chromosomal positions (x axis). The top imputed SNP in each combined analysis is shown as a large triangle and is labelled by its rsID. The colour intensity of each symbol reflects the extent of LD with the top SNP: white (r² = 0) through to dark red (r² = 1.0), with r² estimated from the 1000 Genomes Phase 1 data. Genetic recombination rates (cM/Mb), are shown with a light blue line. Physical positions are based on NCBI build 37 of the human genome. Also shown are the relative positions of genes and transcripts mapping to each region of association. The lower panel shows the chromatin state segmentation track (ChromHMM).