Table 1. Summary statistics for variants showing an association with CRC risk at P < 1.0 × 10 −7 .
|
Individual study
P-values |
Meta-analysis |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | Nearest gene(s) | SNP | Position (bps) | Alleles | RAF | INFO | UK1 | Scotland1 | VQ58 | CFR1 | CFR2 | COIN | OR (95% CI) | P | Phet |
| 1p36.12 | WNT4/CDC42 | rs72647484 | 22,587,728 | TC | 0.91 | 0.94 (0.85-0.99) | 3.25 ×10−2 | 3.32 ×10−5 | 4.99 ×10−2 | 4.08 ×10−2 | 4.58 ×10−2 | 3.47 ×10−2 | 1.24 (1.15-1.33) | 1.21 ×10-8 | 0.33 |
| 5q15 | ERAP1 | rs202110856 | 96,129,872 | GGC | 0.99 | 0.79 (0.66-0.92) | 2.97 ×10−1 | 5.96 ×10-8 | 2.81 ×10−2 | 4.43 ×10−1 | 3.35 ×10−1 | 3.67 ×10−1 | 1.51 (1.23-1.86) | 6.67 ×10-8 | 0.13 |
| 10p13 | CUBN | rs10904849 | 16,997,266 | GT | 0.68 | 0.98 (0.97-1.00) | 2.90 ×10−2 | 3.39 ×10−1 | 2.36 ×10−2 | 8.68 ×10−3 | 7.73 ×10−2 | 1.29 ×10−3 | 1.13 (1.08-1.19) | 7.01×10-8 | 0.83 |
| 16p13.2 | C16orf72 | rs79900961 | 9,297,812 | GA | 0.98 | 0.70 (0.61-0.74) | 2.21 ×10−1 | 8.68 ×10−2 | 1.04 ×10−3 | 2.54 ×10−2 | 2.41 ×10−1 | 1.02 ×10−3 | 1.49 (1.26-1.76) | 4.93 ×10-8 | 0.76 |
| 16q24.1 | FOXL1 | rs16941835 | 86,695,720 | GC | 0.21 | 0.97 (0.92-0.99) | 1.04 ×10−1 | 1.17 ×10−1 | 1.57 ×10−4 | 3.74 ×10−3 | 1.25 ×10−2 | 3.65 ×10−1 | 1.16 (1.09-1.22) | 5.06 ×10-8 | 0.40 |
For each variant shown along with meta-analysis test statistics are the P-values from the six individual studies and imputation Information scores. Risk alleles are given in bold.
INFO, imputation Information score; P-het, P-value of heterogeneity between studies; RAF, risk allele frequency.